Farnaz Faroughi; Sakineh Mohammad-Alizadeh Charandabi; Yousef Javadzadeh; Mojgan Mirghafourvand
Volume 20, Issue 7 , July 2018, , Pages 1-9
Abstract
Background: Women with borderline gestational diabetes mellitus (BGDM) have a higher risk of complications in comparison with normal women. Objectives: The aim of this study was to determine the effects of garlic pill on fasting blood sugar (FBS) and relapse of prediabetes symptoms (primary outcomes), ...
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Background: Women with borderline gestational diabetes mellitus (BGDM) have a higher risk of complications in comparison with normal women. Objectives: The aim of this study was to determine the effects of garlic pill on fasting blood sugar (FBS) and relapse of prediabetes symptoms (primary outcomes), as well as blood pressure, neonatal anthropometric indices, and mode of delivery (secondary out- comes) in prediabetic pregnant women.Methods: This triple-blind, randomized clinical trial was conducted on 49 women with prediabetes at 24 to 28 weeks of gestation in Tabriz, Iran, during 2015 - 16. The participants were assigned to the intervention (n, 26) and control (n, 23) groups using block randomization. The intervention group received a 400-mg garlic pill per day, while the control group received a placebo pill per day for eight weeks. Four and eight weeks following the intervention, FBS and blood pressure were measured. The newborns’ an- thropometric indices and mode of delivery were also recorded after delivery.Results: The mean FBS level in the garlic group decreased from 106.6 (11.1) mg/dL before the intervention to 83.6 (6.3) mg/dL at four weeks after the intervention and 79.4 (6.1) mg/dL at eight weeks after the intervention (adjusted mean difference, -3.7). The garlic pill also led to a significant decrease in prediabetes symptoms at four weeks after the intervention (P < 0.001) and diastolic blood pressure at four and eight weeks after the intervention (P = 0.041), compared to the control group. No significant difference was observed between the groups in terms of systolic blood pressure at four and eight weeks after the intervention, anthropometric indices, or mode of delivery.Conclusions: The results revealed that garlic pill could reduce FBS level, prediabetes symptoms, and diastolic blood pressure. How- ever, further research with a larger sample size is required for more accurate results.
Pari Rahi; Mojgan Mirghafourvand; Sakineh Mohammad-Alizadeh-Charandabi,; Yousef Javadzadeh
Volume 19, Issue 10 , October 2017, , Pages 1-8
Abstract
Objectives: To compare the effects of mefenamic acid versus quince on menorrhagia and quality of life.Methods: This randomized controlled trial was conducted on women with menorrhagia. The participants were allocated into 2 groups through block randomization. The first group (n, 72) received quince pills, ...
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Objectives: To compare the effects of mefenamic acid versus quince on menorrhagia and quality of life.Methods: This randomized controlled trial was conducted on women with menorrhagia. The participants were allocated into 2 groups through block randomization. The first group (n, 72) received quince pills, while the second group (n, 74) used mefenamic acid pills for 3 consecutive cycles. The participants completed the pictorial blood loss assessment chart (PBAC) before and during the intervention. Moreover, the short-form health survey (SF-36) was completed before and 3 months after the intervention.Results: The mean PBAC scores decreased significantly in both groups. The mean PBAC score in the quince group decreased from 173.6 (SD, 53.8) before the intervention to 116.7 (51.7), 86.4 (43.1), and 68.9 (36.4), respectively in the first, second, and third months after the intervention. The mean PBAC scores in the mefenamic acid group was 176.8 (54.3) at baseline and 106.6 (50.40), 81.6 (38.7), and 63.8 (33.8), respectively in the first, second, and third months after the intervention. There was no significant difference between the groups in terms of the mean PBAC score (P = 0.183). Similarly, after the intervention, there was no significant difference between the groups in terms of physical health (P = 0.476) and mental health (P = 0.572) components of quality of life.Conclusions: Quince pills were as effective as mefenamic acid pills in reducing the intensity of menstrual bleeding. Therefore, they seem to be a proper alternative for mefenamic acid.
